The structure of EBOV L-VP35-RNA complex (conformation 1)
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8jsm
Q-score: 0.495
Peng Q, Yuan B, Cheng J, Wang M, Gao S, Bai S, Zhao X, Qi J, Gao GF, Shi Y
Nature (2023) 622 pp. 603-610 [ DOI: doi:10.1038/s41586-023-06608-1 Pubmed: 37699521 ]
- Polymerase cofactor vp35 (37 kDa, Protein from Ebola virus)
- The leader sequence of ebov genome. (5 kDa, RNA from Ebola virus)
- The structure of ebov l-vp35-rna complex (conformation 1) (Complex from Ebola virus)
- Zinc ion (65 Da, Ligand)
- Rna-directed rna polymerase l (252 kDa, Protein from Ebola virus)
The structure of EBOV L-VP35-RNA complex (conformation 2)
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8jsn
Q-score: 0.475
Peng Q, Yuan B, Cheng J, Wang M, Gao S, Bai S, Zhao X, Qi J, Gao GF, Shi Y
Nature (2023) 622 pp. 603-610 [ DOI: doi:10.1038/s41586-023-06608-1 Pubmed: 37699521 ]
- The structure of ebov l-vp35-rna complex (conformation 2) (Complex from Ebola virus)
- The leader sequence of ebov genome (5 kDa, RNA from Ebola virus)
- Polymerase cofactor vp35 (37 kDa, Protein from Ebola virus)
- Zinc ion (65 Da, Ligand)
- Rna-directed rna polymerase l (252 kDa, Protein from Ebola virus)
Structure of EBOV GP lacking the mucin-like domain with 9.20.1A2 Fab and 6D6 scFv bound
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8dpm
Q-score: 0.505
Yu X, Hastie KM, Davis CW, Avalos RD, Williams D, Parekh D, Hui S, Mann C, Hariharan C, Takada A, Ahmed R, Saphire EO
Cell Rep (2023) 42 pp. 113366-113366 [ DOI: doi:10.1016/j.celrep.2023.113366 Pubmed: 37938974 ]
- Antibody 9.20.1a2 fab (Complex from Homo sapiens)
- Glycoprotein gp2 (15 kDa, Protein from Ebola virus - Mayinga, Zaire, 1976)
- Antibody 9.20.1a2 fab heavy chain (13 kDa, Protein from Homo sapiens)
- Antibody 6d6 scfv (25 kDa, Protein from Mus musculus)
- Complex of ebola virus glycoprotein trimer with 1a2 antibody fab and 6d6 antibody scfv (Complex from Ebola virus - Mayinga, Zaire, 1976)
- Antibody 9.20.1a2 fab light chain (11 kDa, Protein from Homo sapiens)
- Glycoprotein gp1 (31 kDa, Protein from Ebola virus - Mayinga, Zaire, 1976)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Lloviu cuevavirus nucleoprotein-RNA complex
Resolution: 3.0356 Å
EM Method: Single-particle
Fitted PDBs: 7ypw
Q-score: 0.407
Hu S, Fujita-Fujiharu Y, Sugita Y, Wendt L, Muramoto Y, Nakano M, Hoenen T, Noda T
Pnas Nexus (2023) 2 pp. pgad120-pgad120 [ DOI: doi:10.1093/pnasnexus/pgad120 Pubmed: 37124400 ]
- Rna (5'-r(p*up*up*up*up*up*u)-3') (1 kDa, RNA from synthetic construct)
- Nucleoprotein (84 kDa, Protein from Lloviu cuevavirus)
- Lloviu cuevavirus nucleoprotein rna complex (Complex from Lloviu cuevavirus)
Lloviu cuevavirus nucleoprotein(1-450 residues)-RNA complex
Hu S, Fujita-Fujiharu Y, Sugita Y, Wendt L, Muramoto Y, Nakano M, Hoenen T, Noda T
Pnas Nexus (2023) 2 pp. pgad120-pgad120 [ DOI: doi:10.1093/pnasnexus/pgad120 Pubmed: 37124400 ]
- Rna (5'-r(p*up*up*up*up*up*u)-3') (1 kDa, RNA from synthetic construct)
- Nucleoprotein (43 kDa, Protein from Lloviu cuevavirus)
- Lloviu cuevavirus nucleoprotein (1-450 residues) rna complex (Complex from Lloviu cuevavirus)
Structure of the Inmazeb cocktail and resistance to escape against Ebola virus
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7tn9
Q-score: 0.475
Rayaprolu V, Fulton BO, Rafique A, Arturo E, Williams D, Hariharan C, Callaway H, Parvate A, Schendel SL, Parekh D, Hui S, Shaffer K, Pascal KE, Wloga E, Giordano S, Negron N, Ni M, Copin R, Atwal GS, Franklin M, Boytz RM, Donahue C, Davey R, Baum A, Kyratsous CA, Saphire EO
Cell Host Microbe (2023) 31 pp. 260- [ Pubmed: 36708708 DOI: doi:10.1016/j.chom.2023.01.002 ]
- Envelope glycoprotein, shed gp (Complex from Mus musculus)
- Regn3479 heavy chain (22 kDa, Protein from Mus musculus)
- Regn3479 light chain (23 kDa, Protein from Mus musculus)
- Inmazeb therapeutic cocktail (Complex)
- Regn3471 heavy chain (23 kDa, Protein from Mus musculus)
- Regn3470 heavy chain (23 kDa, Protein from Mus musculus)
- Regn3471 heavy chain, regn3479 light chain, regn3471 light chain, regn3479 heavy chain, regn3470 heavy chain, regn3470 light chain (Complex from Ebola virus - Mayinga, Zaire, 1976)
- Gp2 (15 kDa, Protein from Ebola virus - Mayinga, Zaire, 1976)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Envelope glycoprotein (35 kDa, Protein from Ebola virus - Mayinga, Zaire, 1976)
- Regn3471 light chain (24 kDa, Protein from Mus musculus)
- Regn3470 light chain (23 kDa, Protein from Mus musculus)
The structure of EBOV L-VP35 complex
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7yer
Q-score: 0.531
Yuan B, Peng Q, Cheng J, Wang M, Zhong J, Qi J, Gao GF, Shi Y
Nature (2022) 610 pp. 394-401 [ Pubmed: 36171293 DOI: doi:10.1038/s41586-022-05271-2 ]
- Zinc ion (65 Da, Ligand)
- The complex of ebov l-vp35 (Complex from Ebola virus)
- Rna-directed rna polymerase l (252 kDa, Protein from Ebola virus)
- Polymerase cofactor vp35 (37 kDa, Protein from Ebola virus)
The structure of EBOV L-VP35-RNA complex (state2)
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7yes
Q-score: 0.49
Yuan B, Peng Q, Cheng J, Wang M, Zhong J, Qi J, Gao GF, Shi Y
Nature (2022) 610 pp. 394-401 [ Pubmed: 36171293 DOI: doi:10.1038/s41586-022-05271-2 ]
- Zinc ion (65 Da, Ligand)
- The complex of ebov l-vp35 (Complex from Ebola virus)
- Rna-directed rna polymerase l (252 kDa, Protein from Ebola virus)
- Vp35 of ebov l-vp35 complex (37 kDa, Protein from Ebola virus)
The structure of EBOV L-VP35 in complex with suramin
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7yet
Q-score: 0.45
Yuan B, Peng Q, Cheng J, Wang M, Zhong J, Qi J, Gao GF, Shi Y
Nature (2022) 610 pp. 394-401 [ Pubmed: 36171293 DOI: doi:10.1038/s41586-022-05271-2 ]
- Rna-directed rna polymerase l (252 kDa, Protein from Ebola virus)
- Polymerase cofactor vp35 (37 kDa, Protein from Ebola virus)
- 8,8'-[carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino]]bis-1,3,5-naphthalenetrisulfon ic acid (1 kDa, Ligand)
- The complex of ebov l-vp35-suramin (Complex from Ebola virus)
Structure of EBOV GP lacking the mucin-like domain with 1C11 scFv and 1C3 Fab bound
Resolution: 3.59 Å
EM Method: Single-particle
Fitted PDBs: 7swd
Q-score: 0.449
Milligan JC, Davis CW, Yu X, Ilinykh PA, Huang K, Halfmann PJ, Cross RW, Borisevich V, Agans KN, Geisbert JB, Chennareddy C, Goff AJ, Piper AE, Hui S, Shaffer KCL, Buck T, Heinrich ML, Branco LM, Crozier I, Holbrook MR, Kuhn JH, Kawaoka Y, Glass PJ, Bukreyev A, Geisbert TW, Worwa G, Ahmed R, Saphire EO
Cell (2022) 185 pp. 995-1007.e18 [ DOI: doi:10.1016/j.cell.2022.02.023 Pubmed: 35303429 ]
- Virion spike glycoprotein gp2 (10 kDa, Protein from Zaire ebolavirus)
- 1c3 light chain (12 kDa, Protein from Homo sapiens)
- 1c3 heavy chain (13 kDa, Protein from Homo sapiens)
- Complex of ebov gp lacking the mucin-like-domain with 1c11 scfv and 1c3 fab (300 kDa, Complex from Homo sapiens)
- Virion spike glycoprotein gp1 (31 kDa, Protein from Ebola virus - Gabon (1994-1997))
- 1c11 scfv (26 kDa, Protein from Homo sapiens)